The Ultimate Antioxidant Cocktail For Poker Players
Before I tell you my personal antioxidant cocktail for mental performance, I want to confess to you a secret of mine. This is hard for me because this is an uncomfortable topic. I truly hate talking about it, but it’s something I think you should know. Some people close to me may consider me to be slightly cheap. I rarely buy anything new. I buy refurbished electronics, used cars, clothes on the clearance rack, and generic medications. My favorite shopping sites are dealnews.com, autotrader.com (I’ve pushed 250 miles before to buy a used car), overstock.com, craigslist.com, and any clothing store that has a clearance page. I honestly can’t remember when was the last time I purchased an article of clothing that wasn’t on clearance. I won’t buy anything with a price tag over $50 without researching it for at the minimum 5 hours. I have to get the best deal possible. I think it’s a disease. I despise paying for something that’s over-priced. Oh hell, I am a cheap bastard. I don’t care because I save money, and that’s money I work too damn hard for to waste on inflated prices.
When it comes to dietary supplements, I am no different. In an industry that’s filled with snake-oils and miracle-cures, I have to be already more alert and aggressive in my research. Like I’ve told you before, I’ve wasted approximately $10,000 over the last 10 years on dietary supplements. Over the last associate of years, I finally wised up, and decided that enough was enough. No longer would I believe what every supplement manufactured told me. I’d first try to perfect my diet, then at any rate supplements I needed thereafter, I’d look to the research for answers. And that’s exactly what I’ve done the last associate of years. Not only has my health improved, but my wallet has gotten heavier too.
Bang for your buck
So why am I confessing to you my cheap lifestyle? I know that after I post my ultimate antioxidant recipe, I will receive numerous e-mails and comments complaining that a certain antioxidant wasn’t included. I can already envision it. Joe Smith: “I can’t believe you didn’t include antioxidant ‘x’. It’s the best antioxidant out there. This just goes to show that you know nothing. You’re a quack.” already though I appreciate negative feedback, I don’t appreciate those kind of e-mails.
This recipe is not the end-all-be-all antioxidant recipe. This recipe gives you the most “bang for your buck.” That’s what my shopping philosophy is all about. The majority of antioxidants I get are from my diet. They come from the fruits and vegetables I eat. However, there are some supplements that already a perfect diet can’t give you enough of. The antioxidants listed below have the most research supporting them along with having a whole lot of real-world feedback. I know a ton of very intelligent people (many times more intelligent than myself) that regularly take these antioxidants on a daily basis. Because of my thrifty lifestyle, I’ve chosen these antioxidants below to cover all of my bases. However, don’t think that because I’m cheap, I’m cutting corners. Health and effectiveness are my top priorities. I would never risk saving a few bucks for quality.
The ultimate antioxidant cocktail for mental performance
Let’s take a minute to refresh why antioxidants are important for mental performance. Your brain uses more energy than any organ in your body. The dominant source of energy is produced from glucose and oxygen. Whenever oxygen is involved in the creation of energy, the risk of free drastic formation is greatly increased. Free radicals are unhealthy substances that bind to anything and everything. When they bind to something that’s advantageous to your health, like cell membranes, the consequence is damage and dysfunction. Antioxidants bind to free radicals, thereby preventing them from damaging your cells. Not only does normal metabolism create free radicals, but so do sunlight, pollution, and your diet. consequently, the brain is under continued free drastic attack. If you don’t have enough antioxidant protection, mental performance will suffer. Side observe: Oxidative stress (free drastic damage) is considered one of the possible causes of Alzheimer’s disease. Research has truly shown that the free drastic damage precedes the disease. There are several clinical studies going on right now that are looking at the advantageous effects of antioxidants in patients with Alzheimer’s disease.
Now let’s get to the cocktail
Vitamin C– anywhere from 1000-2000mg as buffered ascorbate powder or ester-C
Because the body doesn’t manufacture vitamin C, it must come from your diet. already though it’s considered a water soluble vitamin, it’s nevertheless important for proper brain functioning. Its dominant assistance for cognitive health is its ability to help recycle vitamin E, a fat soluble antioxidant. However, that’s not the dominant reason I additional it. I think this next assistance is often over-looked, and almost just as advantageous. A large amount of vitamin C is stored in the adrenal gland. The adrenal gland is considered the stress gland. It releases cortisol and noradrenaline in times of stress. Think flight-or-fight when you think about the adrenal gland. Not only is a large amount of vitamin C stored in the adrenal gland, but it’s thought to play a major role in the creation of noradrenaline. Nor adrenaline, when in the brain, helps keep you awake and energized. A deficiency in vitamin C can rule to a dysfunctional adrenal gland and a decreased amount of noradrenaline, especially during times of mental stress. Cortisol helps raise your blood sugar when it drops too low while noradrenaline stimulates the brain. A dysfunction in either of those will consequence in impaired cognitive performance. Did I mention that it’s extremely cheap?
Vitamin E – 400-1000 IU of d-alpha-tocopherol or the mixed tocopherol combination
I’m sure everyone already knows this, but vitamin E is considered by most to be the most important fat soluble antioxidant. Remember, the brain is largely composed of fat. consequently, it helps to continue the stability and integrity of the brain cell’s membranes. I don’t want to go into too much detail because there is a ton of research supporting this. The majority of its benefits have been in the news for quite some time. A simple search on Google will give you a list of benefits.
R-Alpha lipoic acid -300-1000mg per day
I’m absolutely in love with this nutraceutical. Every month or so, a study comes out touting a new assistance of alpha lipoic acid. It’s been used in peripheral neuropathy, blood glucose regulation, and cognitive disorders. Not only is it water-soluble, but it’s also fat soluble. consequently, it can get anywhere in the body. In addition, it fights a large number of different free radicals such as peroxyl, peroxynitrite, hydroxyl, alkoxyl, and superoxide radicals, among many others. It also helps to recycle glutathione, vitamin E, and coenzyme Q10, all important antioxidants. On top of its antioxidant similarities, it’s also important in cellular energy production. It’s been shown to enhance mitochondrial function, neural blood flow, and nerve conduction along with upregulating several different enzymes that offer neural protection. The R isomer has been shown to be more powerful than the S isomer. consequently, I recommend selecting a product that just includes the R-isomer instead of the combination.
Green Tea Extract – anywhere from 400-1200mg of EGCG
When most people hear Green tea, they think of fat-loss. Yes, it’s great for weightloss, however its benefits don’t stop there. It’s also a very powerful antioxidant. It’s truly made up of several different nutraceuticals, including caffeine, theanine, and EGCG, what I’m particularly interested in. EGCG is currently involved in clinical trials that include allergies, Alzheimer’s disease, bladder cancer, breast cancer, cervical cancer, heart disease, diabetes, immune disorders, metabolic syndrome, stroke, among others. Needless to say, I’m a huge fan. In fact, it’s in my top 3 supplements that everyone should take. Can you guess the other two? Magnesium and fish oil.
In addition to its antioxidant similarities in the brain, it has also been theorized that green tea prevents the breakdown of noradrenaline. I’ve already discussed the stimulatory effects on noradrenaline in the CNS. With these two “brain benefits”, green tea is a must for the poker specialized. I recommend taking the extract capsules because it becomes inconvenient to drink the large amount of green tea that’s required to reach the above dosage.
There you have it. That is my ultimate antioxidant cocktail for mental performance. Cheap, in addition extremely effective. I potential that you won’t be disappointed. Begin taking it now. Not only does it help you in the future, but you’ll feel the benefits within a associate weeks. Energy and antioxidants. Your brain will love you for it.
Here are just a few studies on alpha lipoic acid and its neuroprotective similarities. Before you criticize that these studies include mice, Alzheimer’s patients, and patients with other neurodegenerative disorders, I know. However, I just wanted you to read them first. I’ll explain later this week the value behind these studies, and what they average for the average, healthy person. There are little pieces of gold sprinkled throughout these studies. Mark my words, there will be a prescription medication in the future that contains some form of alpha-lipoic acid. Now whether it’s for Alzheimer’s Disease, diabetic neuropathy, or another condition, I don’t know. However, the clinical evidence for ALA is mounting. Where there’s clinical evidence, there’s future prescription drugs. Look at fish oil and the prescription medication Lovaza. I guarantee it.
Alpha-lipoic acid as a new treatment option for Alzheimer’s disease–a 48 months follow-up examination.
Hager K, Kenklies M, McAfoose J, Engel J, Munch G.
Department of Medical Rehabilitation and Geriatrics, Henriettenstiftung, Hannover, Germany.
Oxidative stress and neuronal energy depletion are characteristic biochemical hallmarks of Alzheimer’s disease (AD). It is consequently conceivable that pro-vigorous and antioxidant drugs such as alpha-lipoic acid might delay the onset or slow down the progression of the disease. In a past study, 600mg alpha-lipoic acid was given daily to nine patients with AD (receiving a standard treatment with choline-esterase inhibitors) in an open-label study over an observation period of 12 months. The treatment led to a stabilization of cognitive roles in the study group, demonstrated by continued scores in two neuropsychological tests (the mini mental state exam, MMSE and the Alzheimer’s disease assessment score cognitive subscale, ADAScog). In this report, we have extended the examination to 43 patients over an observation period of up to 48 months. In patients with mild dementia (ADAScog The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.
Institute for Brain Aging and Dementia, University of California, 1261 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA. [email protected]
We have identified a group of nutrients that can directly or indirectly protect mitochondria from oxidative damage and enhance mitochondrial function and named them “mitochondrial nutrients”. The direct protection includes preventing the generation of oxidants, scavenging free radicals or inhibiting oxidant reactivity, and elevating cofactors of defective mitochondrial enzymes with increased Michaelis-Menten continued to stimulate enzyme activity, and also protect enzymes from further oxidation, and the indirect protection includes repairing oxidative damage by enhancing antioxidant defense systems either by activation of phase 2 enzymes or by increase in mitochondrial biogenesis. In this review, we take alpha-lipoic acid (LA) as an example of mitochondrial nutrients by summarizing the protective effects and possible mechanisms of LA and its derivatives on age-associated cognitive and mitochondrial dysfunction of the brain. LA and its derivatives enhance the age-associated decline of memory, enhance mitochondrial structure and function, hinder the age-associated increase of oxidative damage, elevate the levels of antioxidants, and restore the activity of meaningful enzymes. In addition, co-administration of LA with other mitochondrial nutrients, such as acetyl-L: -carnitine and coenzyme Q10, appears more effective in improving cognitive dysfunction and reducing oxidative mitochondrial dysfunction. consequently, administrating mitochondrial nutrients, such as LA and its derivatives in combination with other mitochondrial nutrients to aged people and patients experiencing from neurodegenerative diseases, may be an effective strategy for improving mitochondrial and cognitive dysfunction.
Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid.
Manda K, Ueno M, Moritake T, Anzai K.
National Institute of Radiological Sciences, Chiba-shi-263-8555, Japan. [email protected]
Reactive oxygen species are indicated in neurodegeneration and cognitive disorders due to higher vulnerability of neuronal tissues. The cerebellum is recently reported to be involved in cognitive function. consequently, present study aimed at investigating the role alpha-lipoic acid against radiation-induced oxidative stress and antioxidant position in cerebellum and its correlation with cognitive dysfunction. We observed instinctive motor activities and spatial memory task of mice using pyroelectric infrared sensor and programmed video tracking system, respectively. Whole body X-irradiation (6 Gy) of mice significantly impaired the reference memory and motor activities of mice. However, acute intraperitoneal treatment of mice with alpha-lipoic acid prior to irradiation considerably attenuated such cognitive dysfunction. Alpha-lipoic acid pretreatment exerted a very high extent of protection against radiation-induced augmentation of protein carbonyls and thiobarbituric acid reactive substance (TBARS) in mice cerebellum. Further, radiation-induced deficit of total, nonprotein and protein-bound sulfhydryl (T-SH, NP-SH, PB-SH) contents of cerebellum and plasma ferric reducing strength (FRAP) was also inhibited by alpha-lipoic acid pre-treatment. additionally, alpha-lipoic acid treated mice showed an intact cytoarchitecture of cerebellum, higher counts of intact Purkinje cells and granular cells in comparison to untreated irradiated mice. Results clearly indicate that alpha-lipoic acid is potent neuroprotective antioxidant.
Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias.
Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Münch G.
Department of Biochemistry and Molecular Biology and Comparative Genomics Centre, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social ecosystem and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment – particularly for the early stages of disease – remains unavailable for clinical use. In this review, we improvement the suggestion that lipoic acid (LA) may fulfil this therapeutic need. A naturally occurring precursor of an basic cofactor for mitochondrial enzymes, including pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KGDH), LA has been shown to have a variety of similarities which can interfere with pathogenic principles of AD. For example, LA increases acetylcholine (ACh) production by activation of choline acetyltransferase and increases glucose uptake, consequently supplying more acetyl-CoA for the production of ACh. LA chelates redox-active change metals, consequently inhibiting the formation of hydroxyl radicals and also scavenges reactive oxygen species (ROS), thereby increasing the levels of reduced glutathione. Via the same mechanisms, downregulation redox-sensitive inflammatory processes is also achieved. Furthermore, LA can scavenge lipid peroxidation products such as hydroxynonenal and acrolein. The reduced form of LA, dihydrolipoic acid (DHLA), is the active compound responsible for most of these advantageous effects. R-alpha-LA can be applied instead of DHLA, as it is reduced by mitochondrial lipoamide dehydrogenase, a part of the PDH complicate. In this review, the similarities of LA are explored with particular emphasis on how this agent, particularly the R-alpha-enantiomer, may be effective to treat AD and related dementias.
Ok, Ok, I know what you’re thinking. How in the hell are these studies going to convince me to start using alpha lipoic acid (R-ALA)? Stay with me for a minute. I potential I’ll show you how you’ll assistance from these studies.
Patents = BIG money
First and foremost, finding clinical studies supporting nutraceuticals is almost like finding a needle in a haystack. Rarely will you be able to find a study that fully supports your research. Why? There’s no money in it. I think I used this example before, but it’s so true, you need to hear it again. The majority of clinical studies are funded by drug companies. It’s a love-hate relationship between drug companies and the medical field. We hate the drug companies because they control the majority of medical information and tend to be biased as to what works and what doesn’t. already my pharmaceutics lab was completely funded by Pfizer, rightfully nicknamed Pfizerceutics. However, we love them because they dump a ton of money into research. Without their sustain, major medical advances would be far and few between. One study (and it doesn’t already have to be well designed) showing a drug’s superiority can make a HUGE profit for a drug company, several hundreds of millions of dollars worth, because of this nifty idea called a drug patent.
Dietary supplements and snake oil
That’s not the case when it comes to nutraceuticals and nutrition. There’s no such thing as a patent when it comes to “natural” therapies. If a study shows that nutraceutical “x” can cure cancer, thousands of companies would flood the market with that nutraceutical thereby wiping out any profit you’d hope to have. On top of that, the dietary supplement industry is largely unregulated. It’s the FDA’s responsibility to prove that a dietary supplement is unsafe or ineffective, not the company selling the product. consequently, already if a study does prove the nutraceutical is effective, there are so many companies that will sell either a diluted-down version of it or something slightly different to make a larger profit that it tarnishes that nutraceutical’s reputation. That was exactly what happened with Hoodia. One version of Hoodia truly does suppress appetite quite well. However, it’s expensive and hard to get. So what did these dietary supplement companies do? Flood the market with bad versions of Hoodia.
consequently, what I’m trying to say, is you have to be very thorough when you read a clinical study, especially involving nutraeuticals. It takes a trained eye to find possible biases, design flaws, and sometimes straight-up lies in a clinical study. On top of that, you’ll never find the perfect clinical study. consequently, you’ll need to be able to extrapolate information from one study into your current situation. You’ll need a strong understanding of anatomy and physiology along with a watchful eye.
My treasure chest
Case in point, those studies I listed yesterday. To the normal person, if you don’t have a neurological dysfunction or are a mouse, those studies are useless. However, I think they’re gold mines. Why? First, they show that R-ALA contains neuroprotective similarities and may already reverse or stop cognitive decline/dysfunction. Those studies show me exactly how R-ALA accomplishes this, consequently allowing me to estimate whether it makes sense in a physiological way. Which it does. In fact, 6 years ago when I began looking at R-ALA, the mechanism of action behind it made sense. Now I have studies supporting this.
Secondly, already though those studies involved people at the far end of the cognitive extent, I strongly believe that everyone will experience cognitive decline, already more so now than 50 years ago. Today pollution, pesticides, our diet, medications, and our general lifestyles are killing our brain cells. Just take a look at the number of “new” neurodegenerative diseases people are being diagnosed with. Take a look at the number of psychological diseases that have been produced in the last 10 years. The medical community, along with the general public, is completely overlooking brain health. We’re so focused on cholesterol, blood pressure, blood sugar levels, etc that we don’t already stop to think about our brains. Everyone, young and old, is experiencing cognitive decline RIGHT NOW.
Yes, these studies were done on a cohort of people and animals that I am not a part of. However, I find more similarities between myself and these studies, than I do differences. These studies tell me one thing: R-ALA, from a physiological standpoint, is neuroprotective. That, to me, speaks volumes. If numerous clinical studies are evaluating R-ALA’s effectiveness for different medical conditions, then someone somewhere more intelligent than myself knows just how important R-ALA is. Clinical studies cost way too much money to be conducted on guesses.
In addition, 3 of those 4 studies are comparatively well done. The 4th study is truly a review. They’re all making the exact same conclusion: R-ALA reduces the amount of oxidative stress associated with free radicals consequently resulting in its neuroprotective similarities. One conclusion by all 4 studies. Impressive.